Mitochondrial proteins fine-tune CD8+ T cell metabolism to limit immune damage during tuberculosis response.
Much of current immunology research in is founded on enormous data sets, complex interactions, and computer modeling - tackling the microbiome or the origins of autoimmune disease, for example. Fundamental discoveries can seem few and far between amidst Big Data (data sets of size and complexity that computers are required for analysis, ‘-omics (proteomics, genomics, … Continue reading Location Location Location – T cell receptor placement makes or breaks immune response speed!
The history of medicine and epidemiology is full of “bad bug” stories---bacteria have a reputation for causing many horrible diseases like cholera and tuberculosis. More recently, however, research efforts like the Human Microbiome Project have turned to investigating the role that “ good bacteria” plays in everyday health. The human microbiome is complex, and consists … Continue reading When friend becomes foe: gut bacteria triggers autoimmunity in mice and humans
In 1909, a German scientist named Paul Ehrlich made a simple yet shocking proposal: that cancer arises in our bodies quite frequently, but that it is usually eliminated by cells of the immune system before tumors form. Although radical at the time, Ehrlich’s theory gained experimental support in the mid-to-late 20th century, and it is … Continue reading MHC class I: a novel mediator of the “don’t eat me” signal
Zika virus (ZIKV) has emerged as a significant human health threat in the last 5 years. Zika virus is associated with (and may cause) microencephaly and neurological deficits in infants, with unknown long-term consequences for adults. In late 2015 there was a spike in ZIKV infections in South America. Initially, the surge was blamed on … Continue reading Mosquito spit gives Zika virus an infectious edge
One of the most well-studied and highly utilized animals in biomedical research is the mouse Mus musculus. Although their well-characterized biology makes them a useful, tractable model species, some scientists argue that, as captive animals reared under atypical conditions, their immune systems may be different from that of wild mice.